From: Rankin, Dr. Jeanne
Sent: Friday, March 30, 2007 2:06 PM
Subject: FW: EHV-1 Vaccine Update from APHIS

APHIS' Veterinary Services received a number of questions on EHV-1 vaccines during a call with NASDA.  In response, we put together the following information.  Please review and share with your staffs and other interested parties.  Thanks very much.

Equine Herpesvirus Type 1 (EHV-1) Vaccine Update

Equine Herpes Virus Type 1 (EHV-1) causes a serious disease of horses, equine rhinopneumonitis.  Typically it causes acute, contagious respiratory disease with fever; it can also cause abortion, neurologic disease, and death.  The virus can spread via an infected animal, through the air, or via contaminated equipment, clothing and hands.  An infected animal can be latently infected, sporadically shedding, or show only mild clinical signs.  EHV-1 is endemic to the United States and is usually handled by the states involved.  

An outbreak of neurologic disease caused by EHV-1 occurred in late 2006 and involved a group of 15 horses shipped from Germany .  The horses were subsequently shipped to 8 states.  Five of the horses went to Florida ; this resulted in 13 horses identified as infected, with neurologic signs in 7 cases and 6 associated deaths.  Ten Florida premises were quarantined.  One horse was shipped to California and died shortly after arrival from neurologic disease typical of EHV-1 infection.  The exposed horses were identified, and the horses that were shipped to the remaining 6 states were quarantined and monitored for signs of EHV-1 infection; none were observed.  The Florida outbreak was confirmed as due to neuropathogenic EHV-1 through laboratory confirmation of the presence of neuropathogenic strains of EHV-1 together with observation of clinical signs consistent with the neurologic form of equine rhinopneumonitis.

The U.S. Department of Agriculture’s Animal and Plant Health Inspection Service (APHIS) has been working closely with states in assisting involved parties by tracing the animals’ path from entry to end point.  Most recently, APHIS has been asked to provide information on EHV-1 vaccines.  APHIS would like to take this opportunity to address specific questions received on EHV-1 vaccines:    

Why is there a concern about EHV-1?
EHV-1, in its neuropathogenic form, is emerging with a higher incidence and virulence (i.e., higher morbidity and mortality) than previously seen in the United States .  USDA’s Animal and Plant Health Inspection Service (APHIS) understands the importance of responding quickly to EHV-1 and is addressing vaccine issues.

Are there vaccine products available?
There are currently 35 vaccine products licensed by APHIS’ Center for Veterinary Biologics (CVB) that contain EHV.  These products are labeled as “Equine Rhinopneumonitis” vaccines.  Two products contain only EHV and others are licensed as combination products with additional equine antigens.  There are both modified live virus (MLV) and killed virus products licensed.  All have demonstrated safety, including field safety.  All have demonstrated efficacy in support of the claim on the label (e.g., as an aid in the control of respiratory disease due to EHV-1, as an aid in the prevention of abortion associated with EHV-1, aids in the reduction of shedding).  Label wording is carefully reviewed, must comply with requirements established by APHIS, and be derived from very specific efficacy study observations and results.  Currently, no licensed product has a label claim for the neurologic form of disease caused by EHV-1.  

Have there been cases of the neurologic form of disease caused by EHV-1 associated with vaccination with a MLV EHV-1 vaccine?
To date, the CVB has not received a report of an adverse event involving the appearance of neurologic symptoms following vaccination with a licensed EHV MLV vaccine.  However, APHIS remains vigilant on responding to any possible effects.  Reporting of adverse events is encouraged and adverse events may be reported by telephone at (800) 752-6255, on-line using the Adverse Event Electronic Report Form available at the CVB website (http://www.aphis.usda.gov/vs/cvb), or by fax or mail using the posted form and the provided CVB fax number or address.    

Should owners get their horses vaccinated?
To date, not much is known about the pathogenesis of the neurologic form of equine rhinopneumonitis (EHV-1).  As additional information comes forward, educational outreach to practitioners and horse-owners will be extremely important.  Decisions regarding the use of vaccine containing EHV in individual horses should be made based on the local situation in consultation with your veterinarian.  APHIS will continue to work with the United States Animal Health Association, industry groups, and the National Assembly in formulating further recommendations and plans related to EHV-1.  

For more information on EHV-1 please visit:  http://www.aphis.usda.gov/vs/nahss/equine/ehv/

Karen Eggert
Public Affairs Specialist
301.734.7280
karen.m.eggert@aphis.usda.gov

 

August 15, 2006 For Immediate Release

Sherry Rust, Acting Public Information Officer

Department of Livestock

301 N. Roberts

PO Box 202001

Helena, MT 59620-2001

406-444-9321

Fax 406-444-1929

srust@mt.gov

Equine WNV now confirmed in five Montana counties

Horses in Cascade, Glacier, Phillips, and Yellowstone Counties as well as a second horse in Flathead County have been confirmed with West Nile Virus (WNV), for a total of six equine WNV cases this season, according to Montana Assistant State Veterinarian Dr. Jeanne Rankin.

The first confirmed case, a 2-year old stallion was not vaccinated and was euthanized. Typically approximately one third of clinically affected horses die. Since the first confirmed equine WNV case in 2002 (134 confirmed cases), the total number of infected horses in Montana is 354 with118 deaths and 333 unvaccinated horses. There have been 10 WNV cases confirmed in 2005 and 11 in 2004. The worst year was 2003 with 193 confirmed cases with the last reported case in late October. The age range of animals infected this year is from a 1½-year-old filly to a seven-year-old stallion, which shows the animal does not have to be older or debilitated to become infected with WNV.

"Historically this is about the time of year when the first cases of WNV appear," Dr. Rankin explained, "We have had six cases reported so far this year and we can expect to see this run through September and into October."

"We highly recommend that horse owners talk with their veterinarians about their horses’ risk of getting West Nile Virus and the use of vaccines. It is not too late to vaccinate against West Nile Virus for this year," Dr. Rankin stressed. "With the WNV season possible into late October, there is still time to complete the recommended two initial vaccinations which are given three to six weeks apart."

Effective mosquito control and vaccination are the best safety precautions for your animals against the disease. Watering troughs should be cleaned thoroughly and regularly. A variety of water treatment solutions are available that contain natural bacteria that, when put into the water, will kill fly and mosquito larvae, but is nontoxic to animals. For further information contact Greg Johnson, Entomologist at MSU, or your local county extension agent.

Clinical signs of West Nile Virus in horses include loss of appetite and depression, in addition to any combination of weakness or paralysis of hind limbs, muzzle twitching impaired vision, incoordination, head pressing, aimless wandering, convulsions, inability to swallow, circling, hyperexcitability, or coma.

More information about West Nile Virus in horses is available from the Department of Livestock Web site at www.mt.gov/liv. For information regarding the disease in humans visit www.dphhs.mt.gov

 

Montana has equine shipped semen regulations that require all semen shipped into Montana must have a negative EVA & EIA test current within 6 months of shipping date and a general health inspection.  The permitting process allows the State Veterinarian's Office to verify the requirements have been met.  The permit application is available by either phoning our office at (406) 444-2043 or visiting our website at www.mt.gov/liv in the forms section of Animal Health.  The permitting process and import requirements allow mare owners in Montana a safety net of knowing that a breeding stallion is not a carrier at that time.  Many mare owners are not aware of the potential risk of spreading of disease through shipped semen.  EVA is not strictly passed through reproductive means however.  More information is available regarding this and other diseases.

 
 
-----Original Message-----
From: Linfield, Dr. Thomas
Sent: Monday, July 10, 2006 5:22 PM
Subject: FW: Equine Viral Arteritis (EVA) Outbreak Reported in New Mexico

 
-----Original Message-----
From: Amy Mann [mailto:amywm@bresnan.net]
Sent: Friday, July 07, 2006 11:19 AM
Last week, the American Quarter Horse Association released the following Media Advisory regarding the confirmation of an outbreak of equine arteritis virus (EVA) infection on a American Quarter Horse breeding farm in New Mexico.  A number of horse owners have expressed concern that movement restrictions will be placed on horses moving into or out of New Mexico as a result of the announcement.  Can you let me know if your state is considering restrictions or have placed restrictions as a result of the EVA outbreak reported in New Mexico.  

I'd like also to take the opportunity to remind you that a great deal of information is available about controlling and preventing this infection.  The American Horse Council developed an effective protocol for breeding susceptible mares to EAV carrier stallions, which has been used successfully by many breeders.  In addition, a Uniform Methods and Rules for addressing and preventing EVA outbreaks is available from Dr. Tim Cordes at USDA.  Dr. Cordes also has a very informative video available that provides excellent information on EVA and how to prevent its spread. And of course, if I can be of any assistance in answering questions, please don't hesitate to contact me.  

Sincerely,

Amy

Amy W. Mann
Director
Health and Regulatory Affairs
American Horse Council
1616 H Street, NW, 7th Floor
Washington, DC  20006
703-981-9745 (cell)
202-296-4031 (AHC Office)
202-296-1970 (AHC fax)
website:  www.horsecouncil.org

Media Advisory

June 30, 2006                                                                         For Immediate Release

Equine Viral Arteritis (EVA) Outbreak Reported in New Mexico

On Monday, June 26, 2006, the Office International des Epizooties (O.I.E.) Reference Laboratory for Equine Viral Arteritis at the University of Kentucky College of Agriculture's Maxwell H. Gluck Equine Research Center, confirmed an outbreak of equine arteritis virus infection involving fetal losses among mares on an American Quarter Horse breeding farm in New Mexico.
This was based on the widespread prevalence of high antibody levels to the virus in both mares and stallions, plus virus isolation from the semen of two stallions. On the same day, the outbreak was reported to the New Mexico Livestock Board in Albuquerque, New Mexico, which is now investigating the potential for spread of the infection to other premises.  
The EVA Reference Laboratory is interested in receiving samples from suspected clinical cases of EVA or from animals very recently exposed to semen from either of the virus-shedding stallions. Veterinarians are requested to contact the Gluck Center at (859) 257-4757 before submitting samples.  
For more information about this outbreak or about EVA, the following resources are available:
What is EVA / How is it diagnosed?
http://www.xcodesign.com/aaep/displayArticles.cfm?ID=285
AAEP Guidelines for breeding a mare to an equine arteritis virus-shedding stallion:
http://www.xcodesign.com/aaep/displayArticles.cfm?ID=36
 

 

 

TEXAS COMPANIES CLONING CUTTING HORSES---ViaGen Inc. of Austin , Texas , and Encore Genetics Ltd. of Weatherford , Texas , last week announced the cloning of two champion cutting horses at a charge of $150,000 each. The companies expect to commercially clone as many as 30 more horses during the next 12 months at a rate of $150,000 for the first clone and $90,000 for the second clone (copy) of the same animal.

The cloned horses, both mares, were born to recipient mares – Feb. 19 and March 9 – on Royal Vista Southwest Farms near Purcell , Okla. One of the foals is the clone of a 26-year-old champion cutting horse with lifetime earnings of $381,764.  

So far, cloned cutting horses have not been banned from competing in sanctioned competitions, but other horse organizations and oversight groups already have announced bans on cloned horses racing or being listed in purebred registries. A bill working its way through the Oklahoma legislature would ban cloned horses from competing in races sanctioned by the Oklahoma Horse Racing Commission.  

 

MONTANA REQUIREMENTS FOR EQUINE SHIPPED SEMEN

Horse owners have many choices available these days for breeding options. With the availability of shipped cooled semen and frozen semen for certain breeds, stallions across the nation and internationally are now accessible for breeding to mares.

Disease prevention is a top priority and the Montana Department of Livestock, Animal Health Division is responsible for regulating import requirements for live animal shipments, semen, and biologics for the state.

For breeds allowing shipped cooled semen, the Montana import requirements for stallions include an Equine Infectious Anemia (EIA) test current within the past 6 months, an Equine Viral Arteritis (EVA) test current within the past 6 months, and a general health inspection current within the past 6 months. A permit issued from the Department of Livestock is also required. These regulations must be met prior to the shipment of semen.

Equine Infectious Anemia, sometimes referred to as Swamp Fever, is an infectious and potentially fatal viral disease. There is no vaccine or treatment available for the disease. Primarily transmitted by insects, the animal can be acutely or chronically infected. Animals in the acute stage may develop severe signs and die within 2 to 3 weeks. This may be the most difficult stage to diagnose as signs appear rapidly and often only an elevated body temperature is noted. One-fifth of a teaspoon of blood from a horse with acute EIA contains enough virus to infect 1 million horses. Chronically infected horses may develop recurring clinical signs such as fever, petechial (blood spots on the mucous membranes) hemorrhages, depression, weight loss, dependent edema, anemia, or irregular heartbeat. Equids testing positive have very few options, with most being euthanized.

Equine Viral Arteritis is an acute, contagious respiratory and abortion disease characterized by fever; depression; dependent edema especially of the limbs, scrotum, and prepuce in the stallion; conjunctivitis; nasal discharge; and infrequently, death in young foals. Outbreaks are not always characterized by clinical signs, the majority of cases are asymptomatic. The virus can be transmitted venereally by the acutely infected mare or the acutely or chronically infected carrier stallion. Mares can be infected venereally either by natural service or artificial insemination with infective semen, causing abortion or passing the disease on to the unborn foal, which consequently dies. Carrier stallions are viral reservoirs with the virus being shed constantly in the semen. The infection rate by a carrier stallion is up to 85% of the susceptible mares to which they are bred. Acutely affected stallions may suffer from a period of short-term subfertility.

In an effort to facilitate shipments of semen without compromising the integrity of disease control programs and allowing for the limited time-frame semen is shipped, the Animal Health Division has created an Annual Equine Semen Import Permit. The permit is a single sheet application and is completed and returned back to the Animal Health Division prior to any semen needing to be shipped. Copies of the current EIA and EVA tests along with verification of the most current health inspection must accompany the application. Upon receipt of the application and supporting paperwork, a permit number is issued and a copy returned back to the stallion manager. A copy of the permit is required to be included with each shipment of semen. The permit is applicable per stallion so each individual animal must have a permit. There is no charge for the application or permit.

You may phone the Montana State Veterinarian’s Office at (406) 444-2043 for additional information or to request an application, or visit our website at: www.mt.gov/liv/animalhealth/index.asp

March 17, 2005

Horse Travel Requires Permits and More

(HELENA) -- The amount of horse-related travel into and around Montana increases in the spring, and the Montana Department of Livestock (DOL) has guidelines to ensure the health, safety and ownership of all animals involved.  The guidelines apply to horses coming into the state, leaving the state, and traveling from county to county within Montana.         

Several items are required before a person can bring a horse into the state, according to Montana State Veterinarian Dr. Tom Linfield, and they have certain time requirements attached to them. 

A current certificate of veterinary inspection (CVI), also known as a “health certificate,” issued by an accredited veterinarian in the state of origin is needed. To be a current CVI, it must have been issued within 10 days of the veterinary exam and is only valid for the 30 days following that exam before bringing a horse into Montana.

A negative equine infectious anemia (EIA) test that has been performed in the past 12 months is also required.  The negative EIA test results, test date, and the name of the laboratory conducting the EIA test must be included on the CVI. 

A Montana import permit, issued by the DOL, is required and can be obtained within 10 days prior to transporting a horse into Montana by calling the DOL at 406-444-2976.  This is a 24-hour service. 

In addition, a brand inspection is required for horses entering Montana, as well as those traveling within Montana.  If the state of origin does not have a brand inspection available, one may be obtained upon arrival in Montana by contacting the local sheriff’s office for referral to a brand inspector. 

For complete brand laws and requirements, and a list of brand inspectors, horse owners can call the DOL’s Brands Enforcement Division at 406-444-2045.  The information is also available on the DOL web page at www.mt.gov/liv.   

For Montanans leaving the state with a horse and returning, a CVI is needed for the horse.  This certificate must be issued by an accredited Montana veterinarian and is valid for 30 days to one destination.  A current negative EIA test, a re-entry permit, and a lifetime brand inspection are also required.  A lifetime brand inspection is valid for crossing state lines and is recognized by most states.  The annual brand inspection is valid for crossing county lines within the state only.  An annual re-entry permit is also available for those taking multiple trips outside the state each year.  The annual permit is valid for a calendar year and expires on Dec. 31. 

        Horse owners should always check the brand and health requirements for the states they will be traveling to prior to departure.  “During certain times of the year, there may be disease outbreaks, either in Montana or destination states,” Dr. Linfield said.  “If travel includes one or more states where disease is occurring, additional restrictions may apply to enter those states and for return to Montana.”  In addition, some states require a negative EIA test within 6 months, rather than within 12 months.

For residents and horses traveling within the state, a brand inspection is required to cross county lines.  The inspection may be either a trip permit, an annual inspection that expires 12 months from the date it is issued, or a lifetime brand inspection that is valid for the entire time the listed owner retains ownership of the horse.
        For imported horses, a current negative EIA, or coggins test, is required because of the severity of the disease and because the disease is contagious.  EIA, also known as Swamp fever, is a viral disease, most often transmitted by biting flies, such as horse flies or deer flies.  The disease is characterized by intermittent fever, depression, progressive weakness, weight loss, edema, and progressive or transitory anemia, as well as occasional neurological manifestations.  The virus causes a lifetime infection in horses and there is no cure for EIA. 

“It is also recommended that a buyer obtain a recent negative EIA test on any horse purchased,” Dr. Linfield  added.  An EIA test is not required on change of ownership within the state, but will help prevent inadvertent spread of the disease.  In addition, some shows, events or sales within Montana may require that participating horses have current negative EIA tests.

For more information contact:
_____________________________

Karen R. Cooper, APR
Public Information Officer
Montana Department of Livestock
PO Box 202001
Helena, MT 59620-2001
406-444-9431
406-444-4316 fax
kcooper@mt.gov
*** please note new email address
      for your records ***
_______________________

 

 

COLORADO STATE UNIVERSITY VETERINARIANS REPORT UNUSUAL RISE IN CASES OF PIGEON FEVER AMONG COLORADO HORSES


FORT COLLINS - Equine veterinarians at Colorado State University's James L. Voss Veterinary Teaching Hospital report a serious increase in the number of cases of pigeon fever they have treated since early fall and warn horse owners to be alert for signs of the highly contagious disease. Seventy-six cases from Colorado's Front Range have been confirmed by the Colorado State University Veterinary Diagnostic Laboratory since early fall, more than six times the number of cases from last year's total of 12 confirmed cases and far above the seven confirmed cases in 2000."What was once considered a disease of California horses is now a growing problem for the Colorado equine population," said Andrea Torres, veterinarian and microbiology resident who conducted a study of the disease in Colorado in 2000-2001. "The increased number of confirmed cases may be due to a more educated horse-owning public and/or to more veterinarians being aware of the disease and testing for it."Torres and other veterinarians at the hospital point out that the signs of pigeon fever can also initially resemble those of other diseases such as strangles. Sometimes the only initial signs are lameness and a reluctance to move.Pigeon fever, also called pigeon breast, breastbone fever, false strangles, dryland strangles or dryland distemper, is caused by Corynebacterium pseudotuberculosis and is found worldwide. It can strike a horse of any age, sex or breed, but usually attacks young adult animals. There is a low incidence in foals.It has also been diagnosed in cattle, and a similar disease affects sheep and goats. The disease is not transmissible to humans (Note: Information from Utah State University and Dr Bowen, a veterinarian from KY said it can be transmissible to humans, but is rare and only in patients with suppressed immune systems, such as an AIDs patient. It’s still is good to wear gloves or wash your hands after being close to the lesions). Humans can carry the infectious agent on shoes, clothing, hands or barn tools and transfer it to another animal.Clinical signs include lameness, fever, lethargy and weight loss and usually is accompanied by very deep abscesses and multiple sores along the chest, midline and groin area and, sometimes, the back. Abscesses also can develop internally.The disease is called pigeon fever because infected animals often develop abscesses in their pectoral muscles, which swell and resemble a pigeon's chest. Although the disease is considered seasonal, with most cases occurring in early fall, a number of cases have been confirmed during winter months and other times of the year as well.The causative bacteria live in the soil and can enter the animal's body through wounds, broken skin or through mucous membranes. Additionally, some researchers believe pigeon fever may be transmitted by flies.The disease occurs in three forms: external abscesses, internal abscesses and limb infection, also known as ulcerative lymphangitis. The most common forms are external abscess and lymphangitis, with the prognosis of a full recovery being generally good. Internal abscesses are much more difficult to treat."Because this disease is so highly contagious, it is very important that veterinarians accurately diagnose these cases to tailor treatment and control," said Torres."Horse owners should be aware of the clinical signs and understand that veterinary care must be timely. Infected horses should be isolated, the abscesses properly treated and the drainage properly disposed of. The area where the infected horse is kept must be properly cleaned and completely disinfected because this is a very hardy bacterium. Pest control is extremely important"As a service to horse owners, Colorado State's equine veterinarians have created a fact sheet on pigeon fever (attached) that is posted on the Colorado State University website at www.cvmbs.colostate.edu/vth and www.colostate.edu on the news page.

FACT SHEET: PIGEON FEVER IN EQUINES

Common Names:
Pigeon fever, pigeon breast, breastbone fever, dryland distemper, dryland strangles, false strangles, false distemperGeographic Incidence: Endemic to California, but now found in most Western states in the U.S.Seasonal: Usually appears in late fall but can appear sporadically at any time of year.

Cause: Corynebacterium pseudotuberculosis

Vaccine: None at this time.

Reservoirs and mode of transmission: Can live in the soil and enter the horse's body through wounds or broken skin and through mucous membranes.
May possibly be transmitted by flies, including the common housefly and horn flies.
Disease is usually highly contagious and can easily infect multiple horses on the premises.
Bacterium in the pus draining from abscesses on infected horses can survive from one to 55 days in the environment. It has also been shown to survive from one to eight days on surface contaminants and from seven to 55 days within feces, hay, straw or wood shavings.
Lower temperatures prolong the survival time.

Clinical signs: Early signs can include lameness, fever, lethargy, depression and weight loss.
Infections can range from mild, small, localized abscesses to a severe disease with multiple massive abscesses containing liters of liquid, tan-colored pus.
External, deep abscesses, swelling and multiple sores develop along the chest, midline and groin area, and, occasionally, on the back.

Incubation period: Horses may become infected but not develop abscesses for weeks.Animals affected:The disease usually manifests in younger horses, but can occur in any age, sex, and breed.
A different biotype of the organism is responsible for a chronic contagious disease of sheet and goats, Caseous lymphadenitis, or CL. Either biotype can occur in cattle.

Disease forms: Generally 3 types: external abscesses, internal abscesses or limb infection (ulcerative lymphangitis).
The ulcerative lymphangitis is the most common form worldwide and rarely involves more than one leg at a time. Usually, multiple small, draining sores develop above the fetlock.
The most common form of the disease in the United States is external abscessation, which often form deep in the muscles and can be very large. Usually they appear in the pectoral region, the ventral abdomen and the groin area. After spontaneous rupture, or lancing, the wound will exude liquid, light tan-colored, malodorous pus.
Internal abscesses can occur and are very difficult to treat

Diagnosis: Your veterinarian can easily collect a sample for culture at a diagnostic laboratory. It is important to isolate the bacterium to get a definitive diagnosis since pigeon fever can superficially resemble other diseases.

Treatment: Hot packs or poultices should be applied to abscesses to encourage opening. Open abscesses should be drained and regularly flushed with saline.
Surgical or deep lancing may be required, depending on the depth of the abscess or the thickness of the capsule, and should be done by your veterinarian.
Ultrasound can aid in locating deep abscesses so that drainage can be accomplished.
External abscesses can be cleaned with a 0.1 percent povidone-iodine solution
Antiseptic soaked gauze may be packed into the open wound
A nonsteroidal anti-inflammatory drug such as phenylbutazone can be used to control swelling and pain
Antibiotics are controversial. Their use in these cases has sometimes been associated with chronic abscessation and, if inadequately used, may contribute to abscesses, according to one study.
The most commonly used antibiotic for the treatment of this condition is procaine penicillin G, administered intramuscularly, or trimethoprim-sulfa.
In the case of internal abscesses, prolonged penicillin therapy is necessary

Care required: Buckets or other containers should be used to collect pus from draining abscesses and this infectious material should be disposed of properly.
Consistent and careful disposal of infected bedding, hay, straw or other material used in the stall is vitally important.
Thoroughly clean and disinfect stalls, paddocks, all utensils and tack.
Pest control for insects is also very important.

Recovery time: Usually anywhere from two weeks to 77 days.

Prognosis: Usually good with complete recovery, although some horses may experience recurrence.

 

 

From: "Linfield, Dr. Thomas" <tlinfield@state.mt.us>
Sent: Thursday, July 08, 2004 4:58 PM
> *******************************************

Stomatitis in equines in Colorado
> ---------------------------------------
> On 2 Jul 2004, an equine premise in Colorado met the index case definition
> for vesicular stomatitis (VS). Later on the same day, a 2nd equine premise
> met the subsequent case definition for VS. The affected premises have been
> placed under quarantine.
> VS is a viral disease which primarily affects horses, cattle, and swine.
The
> virus that causes VS has a wide host-range. VS also occasionally affects
> sheep and goats. In affected livestock, the VS virus causes blister-like
> lesions to form in the mouth, on the dental pad, tongue, lips, nostrils,
> hooves, and teats. These blisters swell and break, leaving raw tissue that
> is so painful that infected animals generally refuse to eat and drink.
They
> also generally show signs of lameness. Severe weight loss usually follows,
> and in dairy cows, a severe drop in milk production commonly occurs.
> Affected dairy cattle can appear to be normal and will continue to consume
> about half of their normal feed-intake.
> The need for increased surveillance and reporting should be communicated
to
> all facilities, and personnel, of the animal disease monitoring network.
> Early detection remains the key to minimizing the impact of such a disease
> introduction.
> Please forward this information to your federal, state, and industry
> counterparts as necessary.
> For additional information on VS, please refer to the following APHIS
> web-page:
> <http://www.aphis.usda.gov/lpa/issues/vs/vs.html>
> If you have any questions about this situation, please feel free to call
the
> Emergency Management Staff at 301-734-8073.
>
> --
> ProMED-mail
> <promed@promedmail.org>
>
> [see also:
> Vesicular stomatitis, equine, bovine - USA (TX, NM) 20040701.1754
Vesicular
> stomatitis, equine - USA (TX, NM) 20040619.1640 Vesicular stomatitis,
equine
> - USA (NM) 20040608.1538 Vesicular stomatitis - USA (TX) (04)
20040529.1466
> Vesicular stomatitis - USA (TX) (03): OIE 20040521.1367 Vesicular
stomatitis
> - USA (TX) (02) 20040520.1354 Vesicular stomatitis - USA (TX)
20040520.1350]
> ....................tg/msp/lm
>
> *##########################################################*
> ProMED-mail makes every effort to  verify  the reports  that are  posted,
> but  the  accuracy  and  completeness  of  the information,   and  of  any
> statements  or  opinions  based thereon, are not guaranteed. The reader
> assumes all risks in using information posted or archived by  ProMED-mail.
> ISID and  its  associated  service  providers  shall not be  held
> responsible for errors or omissions or  held liable for  any damages
> incurred as a result of use or reliance upon  posted or archived material.
> ************************************************************
> Visit ProMED-mail's web site at <http://www.promedmail.org>.
> Send  all  items  for   posting  to:   promed@promedmail.org
> (NOT to  an  individual moderator).  If you do not give your
> full name and  affiliation, it  may  not  be  posted.   Send
> commands  to  subscribe/unsubscribe,   get  archives,  help,
> etc. to: majordomo@promedmail.org.    For assistance  from a
> human  being  send  mail  to:   owner-promed@promedmail.org.

 

HC/HERDA Update; Owners of Carrier Stallions Notified

by: Les Sellnow
5/17/04

Approximately 100 Quarter Horse stallion owners have received, or will receive, a telephone message from Ann Rashmir, DVM, MS, Dipl. ACVS, associate professor of surgery and head of the Hyperelastosis Cutis (HC) Research Program at Mississippi State University, that contains unwelcome news. The message is that the stallion is a carrier of the recessive gene that causes HC, also known as hereditary equine regional dermal asthenia (HERDA).

Being a recipient of that information, says Steven Hanson, a Billings, Mont., attorney as well as a cutting horse exhibitor and breeder, just might serve to place a special responsibility on the stallion owner to reveal to mare owners that the stallion is a carrier.

Rashmir says she has no immediate plans to make the names of the known carrier stallions public.

"I think it is only fair that the owners should be informed first," she said. "They shouldn't have to read about it in a publication. My hope is that they will then make this information available to persons planning to breed mares to their stallion or stallions."

The stallions known to be carriers are those which have sired an HC-affected offspring. Siring even one HC offspring is proof that the stallion is a carrier, says Rashmir.

Rashmir and Nena Winand, DVM, PhD, a geneticist and assistant professor in the Department of Molecular Medicine at Cornell University, announced earlier that 100% of the horses they have studied which are afflicted with HC trace through both sire and dam to Poco Bueno or his immediate relatives--Poco Bueno's sire, King, and Poco Bueno's full brother, Old Granddad. Rashmir and Winand are collaborators on HC research.

What is HC?
When a horse has HC, there is a lack of adhesion within the dermis, the deep layer of skin, due to a collagen defect. Collagen serves as a form of glue that holds the skin layers together. In horses with HC, the "glue" is inferior and the skin layers separate. When the horse is ridden under saddle or suffers trauma to the skin, the outer layer often splits or separates from the deeper layer, or it can tear off completely. It rarely heals without disfiguring scars. New damaged areas arise continuously, sometimes without obvious trauma. Click here to see images of HC/HERDA.

The condition has manifested itself more frequently in cutting horses, but other disciplines are not immune, with cases showing up in reiners and pleasure horses which trace back to Poco Bueno.

Because the condition is caused by a recessive gene, it means that both sire and dam must possess the gene before an offspring of the two will be afflicted. Even when both sire and dam possess the gene, the disease will not necessarily be manifested. Under the laws of genetics, if a carrier is bred to a carrier, 25% of the offspring will have HC, 25% will not be afflicted or be carriers (they'll be genetically normal), and 50% will become carriers but not be afflicted.

One of the reasons that HC rears its head more often in cutting horse circles than any other, it is theorized, is that one of the most popular lines traces back to Poco Bueno through Doc O'Lena and Dry Doc and their dam, Poco Lena, a daughter of Poco Bueno. Both Doc O'Lena and Dry Doc are proven carriers of the recessive HC gene. Through the years, cutting horse breeders have tended to utilize the Doc O'Lena and Dry Doc bloodlines on both sides of the pedigree--breeding cousins to cousins. In essence, they have created a gene pool of carriers.

"It isn't the horse's fault," says Rashmir. "The problem revolves around the way we have bred them. Carriers have been bred to carriers. Breeders have a responsibility to avoid doing this if they know that stallion and mare are indeed carriers."

This does not mean, she says, that one should avoid the Poco Bueno bloodline when establishing a breeding program.

"If you owned Poco Bueno and knew that he had a genetic flaw, would you have stopped using him as a breeding stallion?" she asked rhetorically. "Not at all. He was a wonderful athlete and a great progenitor, but you would have, or should have, worked around the problem by avoiding inbreeding. It's the same with many of his descendants. They are great athletes and even if they are carriers, it has no effect on their performance capability. Simply having the recessive gene produces no harm to that individual. The problem arises when carrier is bred to carrier, setting the stage for HC to be manifested."

The American Quarter Horse Association (AQHA) is funding research at the University of California, Davis, aimed at finding a genetic marker for the disease. Researchers say they are two to three years away from being able to identify the recessive gene.

AQHA also has funded research at Mississippi State where Rashmir and associates are attempting to establish a protocol for dealing with afflicted horses. While the disease is a death sentence for many, Rashmir said, there has been some progress in developing ways to mitigate the effects of HC. Some afflicted horses, she said, have been able to perform in at least a limited manner.

Owners of Carrier Stallions
What are the legal ramifications when a stallion owner knows that his horse is a carrier? Is he/she bound to disclose that information to mare owners?

We asked attorney Hanson to respond to that question. Here, in part, is what he had to say:

"Because apparently there is no method yet developed to test through tissue biopsy for carrier status in breeding stock, at present the only known method of determining whether a mare or stallion is a carrier, if not themselves affected, is to confirm the existence of the condition in affected offspring. The production of an affected offspring means that both sire and dam are carriers.

"That begs the question of whether the stallion owner should make disclosure once he has knowledge of his sire's carrier status," continued Hanson. "If a mare owner has a known carrier, or a mare with known carrier ancestors, he can avoid producing an affected foal by mating the mare with a non-carrier stallion; but if the mare owner is unaware of a prospective sire's carrier status, and the owner of the stallion does not disclose the stallion's genetic flaw, does the mare owner have a legally enforceable cause of action against the stallion owner in the event the resulting offspring is affected with HC?

"Normally, saying nothing stands a better chance of avoiding legal liability than saying the wrong thing; i.e., speaking falsely or in a manner that misleads," added Hanson. "When dealing with fraud or misrepresentation, however, silence may be construed as actionable.

"Fraud and misrepresentation, as causes of action against the speaker, are usually associated with contract cases where the damaged party was either intentionally or negligently induced to enter into an agreement and then later discovered, to his detriment, that the other party had misrepresented or falsely stated a material fact upon which the damaged party had justifiably relied," Hanson explained. "The other party could even be held liable for damages, whether or not he intended to actually cause harm to the innocent party, if by saying nothing he covered up a fact that is construed as information that would be material to the unsuspecting party in making a breeding decision.

"The courts in such cases give consideration to numerous factors, or elements of proof, and of course each case will be decided on its own merits," he added. "In general, it may be said, however, that failure to disclose a known defect in the quality of the goods which are the subject of the contract could indeed be a basis for an award of damages against the silent non-disclosing party to the contract.

"In the end, even though it may have an adverse impact in the form of reduced breeding fee sales, owners of stallions which are known HC carriers may be placing themselves in legal jeopardy if they fail to make disclosure of the existence of the genetic defect in their breeding sires," Hanson stated. "The duty to disclose may also extend to sellers of young horses which have not exhibited the outward manifestations of HC, but which are the offspring of known carriers."

Hanson has personal experience with HC, although inadvertently. It is a story that is being told here because it demonstrates the insidious manner in which HC can surface.

Hanson purchased a promising son of the late Shorty Lena--tracing back to Poco Bueno through Doc O'Lena and Poco Lena. Wondering if the young horse was stallion material, Hanson offered to breed the stallion, free of charge, to a mare owned by a friend. At the time, Hanson and the mare owner knew little about HC. The mare's granddam, traced directly to Poco Bueno through a grandparent and a great-grandparent.

The mare, bred to Hanson's stallion, produced what appeared to be a quality filly. Before reaching one year of age, however, she manifested clinical signs of HC. A biopsy was sent to Mississippi State University. The diagnosis was hyperelastosis cutis.

Hanson did not face any major decisions as to how to handle the situation because, before learning that the stallion was a carrier, he had decided that standing a stud wasn't for him and the horse was gelded. The mare owner had not paid a breeding fee, so there were no damages from that aspect.

Hanson concluded his remarks on legal obligation involving HC carriers thusly: "The duty to disclose, or lack thereof, presents a moral as well as a legal dilemma. Ethicists may argue the question at length, but in the final analysis, each owner of a known carrier stallion will settle that debate for himself in his own mental wrestling match.

"As to the legal question, persons suffering damage in consequence of misrepresentation by silence are urged to seek the advice of an attorney who can render an opinion after consideration of all the facts and the law of the state which has jurisdiction over the parties and the subject matter of the breeding contract," concluded Hanson.

While there are approximately 100 known carrier stallions, they are only the tip of the iceberg, said both Rashmir and Winand. They fear that there are a great many others which have either sired affected offspring or which have the potential to do so.

Cutting horse trainer James Johnson of Casper, Wyo., purchased a quality two-year-old prospect from a breeder. The horse's lineage traced back to Poco Bueno through Doc O'Lena. Johnson took the horse to his ranch and turned it out in a pasture with some other horses. One day he noticed the colt had what appeared to be a slight tear in the skin on his neck. Johnson surmised that a young Longhorn bull in the same pasture might have been responsible. The wound was treated, but it didn't heal. Later, it appeared to heal, but lesions opened in other parts of the colt's body. Veterinarians were called in and specialists were consulted. Although no biopsy was taken, the conclusion was that the young horse was afflicted with hyperelastosis cutis.

"It was awful," Johnson said. "He just never healed."

The veterinarians said there was nothing further they could do and the youngster was put down.
 The next question is this: Will knowing that a stallion is a carrier dissuade mare owners from breeding to him when the mare might also be a carrier? The answer is sometimes yes, sometimes no. One breeder, who requested anonymity, said he is willing to take his chances breeding carrier to carrier because the bloodlines with which he is involved are producing winners in the cutting pen. He has the financial means to take the risk.

There is another side to the coin. One breeder who feels she has suffered a damaging financial loss due to HC is Cindy Lyles of Haslet, Texas. She bred her mare and did an embryo transfer. When flushed, the mare produced two viable embryos and each was implanted in a surrogate mare. Two foals were born. Both of them demonstrated outward signs of HC early in their lives. Further analyses, including biopsies, proved they were afflicted. Lyles has donated the two colts to the HC research herd at Mississippi State University.

The woman estimates that she has invested $17,000 in the breeding fee, embryo transfers, and veterinary bills. Both sides of the pedigree trace back to Poco Bueno through Doc O'Lena. 

Until a genetic test is established that will determine carrier status, the horse owner is left with guesswork in many cases when Poco Bueno bloodlines are involved. As an assist, Rashmir has offered to analyze pedigrees and provide information concerning the odds of a particular mating producing a foal with HC. The charge for an eight-generation pedigree analysis is $25 with the proceeds going directly to the Mississippi State University HC research fund.

Rashmir also has advised stallion and mare owners to include a provision concerning HC in their breeding contracts in case a foal is affected.

 

JURY AWARDS $1,007,500 IN EQUITROL LAWSUIT

Santa Ana, CA, March 25, 2004 -- The jury in Wrather v. Farnam Companies returned a verdict of $1,007,500 in favor of plaintiffs Charlotte Wrather, Christopher Wrather and Lori Araki. The jury found that Farnam's product EquitrolR, a feed-through fly control product, was defectively designed (not safe when used in the intended manner) and that it had caused harm to plaintiffs' Thoroughbred racehorses and Thoroughbred and Warmblood sport horses. Mr. and Mrs. Wrather are the owners of Cottonwood Ranch in Los Alamos, California, a Thoroughbred breeding and training farm. Ms. Araki is manager and trainer at Cottonwood Ranch.

EquitrolR works in the manure to kill fly larvae before they mature. Its active ingredient is the organophosphate insecticide tetrachlorvinphos, a cholinesterase inhibito r and neurotoxin which is also known by the trade name RabonR. Feed-through fly control products containing RabonR are widely used in beef and dairy cattle and other livestock industries, as well as in horses.

Farnam has advertised that EquitrolR is designed to pass quickly through the horse's gastrointestinal tract without being digested, and that it is safe for all horses including pregnant and lactating mares and their foals. The Wrathers and Ms. Araki claimed that they fed EquitrolR as directed, that the organophosphate in it was absorbed into their horses'systems, and that this caused or exacerbated a variety of health problems in the horses including reproductive problems and birth defects, stunted and retarded growth, hyperexcitability and other neurological dysfunctions, laminitis, immunosuppression evidenced by unusual or unusually severe infections, low thyroid, diarrhea, colic and more. Testifying as an expert witness for plaintiffs was Dr. John Madigan, D.V.M., professor in the Department of Medicine and Epidemiology and chief of the Equine Section at the Veterinary Medical Teaching Hospital, School of Veterinary Medicine at the University of California, Davis. Dr. Madigan last summer conducted a pilot study of the effects of feeding EquitrolR. In his study (forthcoming in the veterinary literature), the group of test horses fed EquitrolR experienced a sharp drop in their whole blood cholinesterase to levels consistent with organophosphate intoxification. The study also revealed statistically significant differences in behavior while on EquitrolR as compared with the control group. In a series of behavioral tests, the horses fed EquitrolR exhibited heightened or intensified flight response, that is, they were "spookier" or more easily startled or frightened.

Also testifying for the plaintiffs were Drs. Mark Rick, D.V.M. and Greg Parks, D.V.M., both of the well known Alamo Pintado Equine Medical Center in Los Olivos, California; Dr. David Jensen, D.V.M., who practices privately as San Marcos Equine Practice in Los Alamos, California; and Dr. Warren Porter, Professor of Environmental Toxicology at the University of Wisconsin at Madison. The Wrathers and Ms. Araki had also alleged that Farnam knew at least since 1981 that 10% to 30% of the organophosphate in EquitrolR was absorbed, so that the advertising and marketing for EquitrolR contained negligent and intentional misrepresentations and omissions. The jury did not find that this had been proved by a preponderance of the evidence.

Charlotte Wrather et al v. Farnam Companies, Inc., United States District Court for the Central District of California, Santa Ana Civil No. 03-967 JVS(RCx)(March 25, 2004)

 

For the latest information on horse disease HERDA, go to:

"Hereditary Disease Research at UC Davis"
http://www.thehorse.com/news.asp?fid=5038

"Inherited Quarter Horse Disease Traces to Poco Bueno"
http://www.thehorse.com/news.asp?fid=5037

Health Section  "The Fatal Flaw", Part One 3/12/04
 http://horsecity.com/stories/031204/hea_herda_KT.shtml

"The Fatal Flaw", Part Two  3/16/04
http://horsecity.com/stories/031604/hea_herda2_KT.shtml

 

Tips for Reducing Your Horse's
West Nile Risk

     Since first being recognized in the United States in 1999, West Nile virus (WNV) has posed a serious threat to horses and humans alike.  In the equine population, the virus is transmitted when a mosquito takes a blood meal from a bird infected with WMV, then feeds on a horse.  While many horses exposed to WNV experience no signs of illness, the virus can cause inflammation of the brain and spinal cord.  In some cases, especially in older horses, WNV can be fatal.
    
     For information about the virus, ask your equine veterinarian for the "West Nile Virus" brochure, produced by the AAEP in conjunction with Bayer Animal Health, an AAEP Educational Partner.  Additional information about WNV can be found on the AAEP's horse-heath Web site, www.myHorseMatters.com.  Type West Nile Virus in the search section.

The American Association of Equine Practitioners, headquartered in Lexington, KY, was founded in 1954 as a non-profit organization dedicated to the health and welfare of the horse.  Currently, AAEP reaches more than 5 million horse owners through its 6,500 members worldwide and is actively involved in ethics issues, practice management, research and continuing education in the equine veterinary profession and horse industry.

Stopping mosquitos is the key to stopping West Nile virus.  Limiting their habitat helps limit the spread of the virus.
Empty sources of standing water.  Mosquitoes lay eggs in standing water.  Here are some tips:

*    Every 2-3 days, drain water from outside pet dishes, garbage cans, buckets,   toys, flower pots, wading pools, pool covers, birdbaths and other objects that can collect water.
*    Discard any old tires and unused containers.
*    Clean gutters
*    Drill holes in the bottoms of recycling bins.
*    Properly treat water in larger pools and home ponds.  Contact your state's department of health for guidelines.
*    Mosquitoes like tall grass and weeds.  Keep these cut.

Here's a tip that was given at a recent gardening forum. Put some water in a white dinner plate and add a couple drops of Lemon Fresh Joy dish detergent. Set the dish on your porch, patio, or other outdoor area. Not sure what attracts them, the lemon smell, the white plate color, or what, but mosquitoes flock to it, and drop dead shortly after drinking the Lemon Fresh Joy/water mixture, and usually within about 10 feet of the plate. Check this out---it works just super! May seem trivial, but it may help control mosquitoes around your home.

 

     



 

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